https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Signal transduction in diffuse intrinsic pontine glioma https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:46767 HIST1H3B/C and H3F3A), altering the epigenetic landscape of primitive oligodendrocyte or astrocyte precursor cells of the pontine region of the brainstem. Lysine‐to‐methionine point mutations at amino acid 27 (H3K27M) co‐occur with alterations in signaling genes, including the receptor tyrosine kinases (PDGFR/KIT/VEGFR/MET/EGFR), activin A receptor (ACVR1), intracellular kinases (PI3K/AKT/mTOR), cyclin‐dependent kinases (CDKs1/4/6), transcriptional regulators (MYCN), and tumor suppressors (PTEN/TP53). This cooperation drives gene expression signatures that inhibit cellular differentiation (ID1/2, Hedgehog) and promotes malignant transformation. Unique to DIPG, is the frequency of co‐occurring sets of genomic insults. However, mapping of the oncogenic signaling pathways activated in response to recurring mutations is unresolved. Herein, known oncogenic signal pathways activated in response to recurring somatic mutations and gene amplifications in DIPG are reviewed. Additionally, an important role for high‐resolution quantitative proteomics/phosphoproteomics in the characterization of signaling cascades are highlighted. These regulate the cell cycle, epigenetics and anti‐apoptotic processes, information critical for the development of improved treatment strategies for DIPG.]]> Wed 30 Nov 2022 11:45:04 AEDT ]]> The role of the retinoids in schizophrenia: genomic and clinical perspectives https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:40464 Wed 27 Jul 2022 13:10:26 AEST ]]> Exploring signal transduction mechanisms in molecularly imprinted polymers for forensic applications https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:15864 Wed 11 Apr 2018 18:14:17 AEST ]]> Degradation of APCcdc²⁰ and APCcdh¹ substrates during the second meiotic division in mouse eggs https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:6544 Wed 11 Apr 2018 16:31:09 AEST ]]> Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:2442 Wed 11 Apr 2018 12:48:34 AEST ]]> Defining the distinct, intrinsic properties of the novel type I interferon, IFNϵ. https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:42974 Tue 14 May 2024 11:55:54 AEST ]]> Oestrogen fuels the growth of endometrial hyperplastic lesions initiated by overactive Wnt/β-catenin signalling https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:43322 Thu 15 Sep 2022 14:43:38 AEST ]]> Modification of crocodile spermatozoa refutes the tenet that post-testicular sperm maturation is restricted to mammals https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:35956 Thu 14 May 2020 15:11:42 AEST ]]> An epidermal-specific ethylene signal cascade regulates trans-differentiation of transfer cells in Vicia faba cotyledons https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:9443 Sat 24 Mar 2018 08:41:33 AEDT ]]> The association between CD36 and Lyn protein tyrosine kinase is mediated by lipid https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:1051 Sat 24 Mar 2018 08:32:13 AEDT ]]> The development of signal transduction pathways during epididymal maturation is calcium dependent https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:2526 Sat 24 Mar 2018 08:31:07 AEDT ]]> Localization and significance of molecular chaperones, heat shock protein 1, and tumor rejection antigen gp96 in the male reproductive tract and during capacitation and acrosome reaction https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:1595 Sat 24 Mar 2018 08:30:41 AEDT ]]> Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:908 Sat 24 Mar 2018 08:30:00 AEDT ]]> Signal transduction in the ductuli efferentes testis of the rat: inhibition of fluid reabsorption by cyclic adenosine 3', 5' - monophosphate https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:1495 Sat 24 Mar 2018 08:28:13 AEDT ]]> An atypical heterotrimeric G-protein γ-subunit is involved in guard cell K<sup>+</sup>-channel regulation and morphological development in Arabidopsis thaliana https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:13247 Sat 24 Mar 2018 08:16:00 AEDT ]]> Intracellular calcium in the fertilization and development of mammalian eggs https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:6554 Sat 24 Mar 2018 07:48:22 AEDT ]]> Localization and significance of molecular chaperones, heat shock protein 1, and tumor rejection antigen gp96 in the male reproductive tract and during capacitation and acrosome reaction https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:59 Sat 24 Mar 2018 07:42:05 AEDT ]]> Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:22251 NTR and the sortilin receptor. Herein, it is shown that proNGF is produced and secreted by breast cancer cells, stimulating their invasion. Using Western blotting and mass spectrometry, proNGF was detected in a panel of breast cancer cells as well as in their conditioned media. Immunohistochemical analysis indicated an overproduction of proNGF in breast tumors, when compared with benign and normal breast biopsies, and a relationship to lymph node invasion in ductal carcinomas. Interestingly, siRNA against proNGF induced a decrease of breast cancer cell invasion that was restored by the addition of non-cleavable proNGF. The activation of TrkA, Akt, and Src, but not the MAP kinases, was observed. In addition, the proNGF invasive effect was inhibited by the Trk pharmacological inhibitor K252a, a kinase-dead TrkA, and siRNA against TrkA sortilin, neurotensin, whereas siRNA against p75NTR and the MAP kinase inhibitor PD98059 had no impact. These data reveal the existence of an autocrine loop stimulated by proNGF and mediated by TrkA and sortilin, with the activation of Akt and Src, for the stimulation of breast cancer cell invasion.]]> Sat 24 Mar 2018 07:17:32 AEDT ]]>